Md Sharif Reza

Our lab examines the chemokines at atomic level to describe their interactions. Chemokines are a superfamily of small (6–10kDa) chemotactic cytokines that function in leukocyte trafficking, recruitment, and activation. We need chemokines to fight the infection, but they can also play a negative role by promoting autoimmune and allergic inflammatory reactions, cancer, atherosclerosis, or other inflammatory disorders. They can work alone or may interact with others to form heterooligomers. These interactions alter the biological activity of individual chemokines. Our aim is to design molecules that will block these interactions and lead to the development of more targeted pharmacological agents with minimal side effects.